Long-Term Effects of Neonatal Exposure to Hydroxylated Polychlorinated Biphenyls in the BALB/cCrgl Mouse
نویسندگان
چکیده
The neonatal mouse model has been a valuable tool in determining the long-term effects of early exposure to estrogenic agents in mammals. Using this model, we compared the effects of 2',4',6'-trichloro-4-biphenylol (OH-PCB-30) and 2',3',4',5'-tetrachloro-4-biphenylol (OH-PCB-61) as prototype estrogenic hydroxylated PCBs (OH-PCBs) because they are reported to exhibit relatively high estrogenic activity both in vivo and in vitro. The purpose of this study was to examine the relationship between estrogenicity and carcinogenicity of OH-PCB congeners. The OH-PCBs were tested individually and in combination to determine whether effects of combined OH-PCBs differed from those of these OH-PCBs alone. We evaluated the long-term effects of neonatal exposure to OH-PCBs with treatment doses that were based on the reported binding affinity of specific OH-PCB congeners to estrogen receptor alpha. BALB/cCrgl female mice were treated within 16 hr after birth by subcutaneous injections every 24 hr, for 5 days. The mice treated with OH-PCB-30 (200 microg/day) or 17beta-estradiol (5 microg/day) showed similar increased incidences of cervicovaginal (CV) tract carcinomas (43% and 47%, respectively). In addition, when mice were treated with OH-PCBs as a mixture, a change in the type of CV tract tumor was observed, shifting from predominantly squamous cell carcinomas to adenosquamous cell carcinoma. From our results, we conclude that the individual OH-PCBs tested were estrogenic and tumorigenic in mice when exposed during development of the reproductive tract. These data support the hypothesis that mixtures may act differently and unexpectedly than do individual compounds.
منابع مشابه
Source Identification and Health Risk Assessment of Polychlorinated Biphenyls (PCBs) in Surface Soils from Vicinity of Arad-Kouh Processing and Disposal Complex, Tehran
Polychlorinated biphenyls (PCBs) can adversely affect human and environmental health according to long-term half-life and persistence in the environment. Therefore, this study was conducted to detect, identify, and health risk assessment of PCBs in surface soils collected from the vicinity of Arad-Kouh processing and disposal complex, Tehran, in 2020. A total of 30 surface soil samples was coll...
متن کاملIncreased risk of endometriosis by long term exposure to xenoestrogens: A case control study in Iranian women
Aims of the study: Endometriosis is a prevalent gynecologic disorder in young women at reproductiveage but the underlying risk factors have not identified yet in Iran and other neighboringcountries. Persistent exposure to environmental endocrine disrupting chemicals (EDCs) in particulardioxins, PAHs and polychlorinated biphenyls (PCBs) with xenoestrogenic potentials have beenhypothesized in the...
متن کاملLong-Term Alterations in Histology and Steroid Receptor Levels of the Genital Tract and Mammary Gland following Neonatal Exposure of Female BALB/cCrgl Mice to Various Doses of Diethylstilbestrol1
The relation of the dosage of diethylstilbestrol (DES) administered neonatally to the incidence and severity of genital tract and mammary gland lesions and to the levels of sex hormone receptors was examined using a mouse model for human intrauterine DES exposure. Female BALB/cCrgl mice received various doses of DES (ranging from 5 x 10 'III 5 /ig daily for the first 5 days of life) or the sesa...
متن کاملLong-term alterations in histology and steroid receptor levels of the genital tract and mammary gland following neonatal exposure of female BALB/cCrgl mice to various doses of diethylstilbestrol.
The relation of the dosage of diethylstilbestrol (DES) administered neonatally to the incidence and severity of genital tract and mammary gland lesions and to the levels of sex hormone receptors was examined using a mouse model for human intrauterine DES exposure. Female BALB/cCrgl mice received various doses of DES (ranging from 5 X 10(-1)-10(-5) micrograms daily for the first 5 days of life) ...
متن کاملDoses of Diethylstilbestrol Neonatal Exposure of Female BALB/cCrgl Mice to Various Levels of the Genital Tract and Mammary Gland following Long-Term Alterations in Histology and Steroid Receptor
The relation of the dosage of diethylstilbestrol (DES) administered neonatally to the incidence and severity of genital tract and mammary gland lesions and to the levels of sex hormone receptors was examined using a mouse model for human intrauterine DES exposure. Female BALB/cCrgl mice received various doses of DES (ranging from 5 x 10 'III 5 /ig daily for the first 5 days of life) or the sesa...
متن کامل